Stereodivergent Attached‐Ring Synthesis via Non‐Covalent Interactions: A Short Formal Synthesis of Merrilactone A
نویسندگان
چکیده
Abstract A strategy to control the diastereoselectivity of bond formation at a prochiral attached‐ring bridgehead is reported. An unusual stereodivergent Michael reaction relies on basic vs. Lewis acidic conditions and non‐covalent interactions re ‐ si facial selectivity en route fully substituted attached‐rings. This divergency reflects differential engagement one rotational isomer system. The successful synthesis an erythro subtarget diastereomer ultimately leads short formal merrilactone A.
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2021
ISSN: ['1521-3773', '1433-7851', '0570-0833']
DOI: https://doi.org/10.1002/ange.202114514